Improvement of Skin Barrier Dysfunction by Phenolic-containing Extracts of Lycium barbarum via Nrf2/HO-1 Regulation
Decrease ROS level and matrix metalloproteinase expression, but also strengthen intrinsic antioxidant defense system including SOD, GSH-Px and CAT, thereby resulting in increased skin collagen content and an improvement of UV-induced skin erythema, thickness and wrinkles. Improved skin barrier functions were highly correlated with increased expression of filaggrin, involucrin and loricrin as well as antioxidant proteins such as Nrf2 and HO-1 in UV-iradiated mice, suggesting that LBE may be promising natural products at a lower cost for the topical application in the treatment of skin diseases with defective barrier function
Protects against UV radiation. Regulates inflammatory processes in the skin. Supports DNA repairing processes.
The carbohydrate profile of Lycium b. fruit extract has a prebiotic effect on the skin microbiome. It can stabilize the natural colonization of the microbial profile on the skin, thereby reducing the colonization or multiplication of harmful bacterial strains.
Harmonization in the bacterial profile on human skin, prevents the development of overgrowth of individual bacterial species. The skin then has a better lipid profile and is better able to defend itself against environmental pollution.
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