Postbiotics

a revolution in healthcare and nutrition

MCB

Postbiotics, as defined by the International Scientific Association for Probiotics and Prebiotics (ISAPP), are:

"Prepared products containing inactivated microbial cells and/or their components that have proven health benefits."

Unlike probiotics, which rely on live microorganisms, postbiotics do not require the survival of microbial cells to provide benefits. They are stable, safe and effective, making them ideal for a wide range of applications in nutrition, medicine and cosmetics.

Methods of production of postbiotics


The production of postbiotics requires precise process control to ensure that the resulting products contain only biologically active and beneficial ingredients. Validated methods include:

01

Fermentation of probiotic cultures 

At MCB Lab, we have developed our proprietary MCB Solid State Fermentation (SSF) process , which combines a solid matrix and optimized fermentation conditions to maximize the production of bioactive compounds. This process is the key to producing high quality postbiotics that meet stringent ISAPP standards.

02

Microbial cell inactivation 

Once fermentation is complete, microbial cells are inactivated, for example by heat treatment or ultrafiltration, ensuring the safety of the product.

03

Validation and quality control 

Each product undergoes testing for bioactive content, safety and stability. Validation includes measuring health effects, for example through in vitro tests or clinical studies.

Applied research on postbiotics: global trends 

Postbiotics is currently one of the fastest growing sectors in health and nutrition. The main areas of applied research include: 

Gut microbiota health 

Research focuses on the role of postbiotics in regulating gut microbiota, improving digestion and preventing inflammation. SCFAs and other metabolites provide nutrition for beneficial microorganisms in the gut. 

Supporting the immune system 

Postbiotics have been shown to be effective in modulating the immune response, which may help in the treatment of autoimmune diseases, allergies or chronic inflammation.

Skin care 

In the cosmetic industry, postbiotics find use as natural antioxidants and skin barrier regenerators.

Preventing dementia and supporting brain function 

Research shows that some metabolites of postbiotics, such as short-chain fatty acids (SCFAs), can improve the gut microbiota-brain axis (gut-brain axis) connection. This has a direct impact on the prevention of neurodegenerative diseases, including dementia and Alzheimer's disease. The bioactive substances produced by postbiotics also support the reduction of inflammatory processes that are associated with these diseases.

Biohacking and personalised care 

Postbiotics play an important role in biohacking - the targeted optimisation of physical and mental function. Products aimed at longevity, improving metabolism and supporting the body's regeneration are at the forefront of modern trends. Thanks to the stability and precise formulation of postbiotics, they can be easily integrated into personalized care and daily regimens focused on health and performance.

Postbiotics: the future of health care 

Postbiotics combine the benefits of scientific research and practical application. Thanks to their stability, safety and wide range of biological effects, they have the potential to become an essential part of personalised medicine, preventive care and sustainable nutrition. 

MCB

At MCB Lab, we follow the latest global trends and deliver products that meet modern needs and improve quality of life. Our innovations in postbiotics are proof that science and technology can deliver solutions that respect human nature while pushing the boundaries of health.

Key components of postbiotics
Postbiotics include a variety of bioactive substances such as:

  • Short chain fatty acids (SCFA): e.g. acetate, propionate, butyrate.
  • Enzymes: catalysts of biochemical reactions.
  • Peptides and proteins: Antimicrobial peptides, enzymes.
  • Exopolysaccharides: Bacteria: beneficial carbohydrates produced by bacteria.
  • Lipid components: fatty acids, phospholipids.
  • Cell wall fragments: peptidoglycan and teichoic acids.
  • Quorum Sensing Molecules: signaling molecules that influence microbial communication.
  • Antioxidants and vitamins: e.g. vitamin K, folate, biotin.
  • Organic acids: e.g. lactic acid, acetic acid.

Benefits of postbiotics

01

Modulation of the immune system

Improves immune response and reduces inflammation.

02

Intestinal health

Promotes intestinal barrier integrity and intestinal microflora balance.

03

Antimicrobial activity.

04

Antioxidant effects

Neutralizes free radicals and protects cells.

05

Metabolic support

Improves nutrient absorption and energy metabolism.

06

Skin health

Reduces inflammation and supports skin barrier function.

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